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Module 6.4 · Topic 5
Module 6.4 · Topic 5
A general function isn't the same as a specific place in the system
"Probably a kinase" is a genuinely useful start. It says nothing about which specific pathway that kinase operates in, what substrate it actually acts on, or what happens downstream once it does — the difference between knowing a word's dictionary definition and knowing how it's actually used in a sentence.
A gene has been annotated as a general enzyme type via BLAST similarity. Would a sequence database alone reveal which specific metabolic pathway that enzyme participates in — its exact upstream substrate and downstream product?
Pathway databases such as KEGG differ from sequence databases in that they:
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