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Module 6.4 · Topic 6
Module 6.4 · Topic 6
A layer even further downstream than the proteome, changing even faster
Genomics and proteomics, back in Molecular Tools, described what these datasets actually measure — static sequence versus dynamic protein composition. This lesson asks the computational question instead: once that data exists, by the thousands or millions of data points, how does anyone actually make sense of it?
The genome is essentially fixed. The proteome changes with expression and modification. Is there a layer even further downstream — one that could change on a timescale of seconds, reflecting a cell's chemistry right now rather than its expression state a few hours ago?
The metabolome, compared to the genome and proteome, is characterised by:
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