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Module 3.1 · Topic 9
Module 3.1 · Topic 9
Why 1-in-2500 doesn't mean what you'd think it means
A recessive genetic disorder affects 1 in 2,500 newborns. Ask most people what fraction of the general population silently carries one copy of the allele, and they'll guess something in the same ballpark — maybe 1 in a few thousand. The real answer is dramatically higher.
If 1 in 2,500 people are homozygous recessive (affected) for a disorder, roughly how many people are heterozygous carriers (one copy, unaffected)?
A recessive disorder affects 1 in 10,000 people. Using Hardy-Weinberg, the approximate carrier frequency is closest to:
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