HELIXPrep › Plant, Animal and Microbial Biotechnology › Animals
Module 5.2 · Topic 2
Module 5.2 · Topic 2
Growing billions of cells that insist on having a surface first
Cell Biology showed that a normal animal cell, floating freely with no matrix to attach to, activates its own death programme — anoikis. Scaling that same cell up to industrial bioreactor volumes runs headfirst into that exact requirement.
Most normal animal cells require attachment to a solid surface to survive and divide. Can these cells simply be grown suspended freely in a large stirred bioreactor, the way microbial or many plant cell cultures are?
Anchorage-dependent animal cells require:
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