HELIXPrep › Recombinant DNA Technology and Other Tools › Recombinant DNA Technology
Module 6.1 · Topic 3
Module 6.1 · Topic 3
What holds a piece of DNA a thousand times larger than a gene
Sequencing an entire genome — the project that eventually produced the Human Genome Project — meant cloning fragments spanning hundreds of thousands, sometimes millions, of base pairs at a time. Nothing from last lesson comes remotely close to that capacity.
A cosmid vector extends capacity to roughly 45,000 base pairs by combining plasmid elements with a phage packaging signal. Could a similar hybrid strategy be pushed even further, into the hundreds of thousands or millions of base pairs?
A cosmid vector is best described as:
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